Cisplatin mitophagy

WebBackground and Objectives: Combination therapy improves the effect of chemotherapy on tumor cells. Magnolol, used in treating gastrointestinal disorders, has been shown to have anti-cancer properties. We investigated the synergistic effect of cisplatin and magnolol on the viability and maintenance of MKN-45 gastric cancer cells. Materials and Methods: … WebOct 12, 2024 · Gastric cancer (GC) is one of the most common tumors worldwide, and cisplatin is a standard chemotherapeutic reagent for GC treatment. However, chemoresistance is an inherent challenge which limits its application and effectiveness in clinic. This study aims to investigate the mechanism of metformin-induced cisplatin …

Chaetomugilin J Enhances Apoptosis in Human Ovarian Cancer …

WebOct 7, 2024 · Chaetomugilin J Inhibits Mitophagy Induced by Cisplatin. Mitophagy is a type of autophagy that eliminates redundant or damaged mitochondria. 26 It plays an important role in mitochondrial function. The expression of pink1 and parkin, which are mitophagy-related proteins, were detected to reflect mitophagy. WebJan 16, 2024 · We examined the sensitivity of 20 human cancer cell lines to X-rays, carbon ions, or cisplatin in a clonogenic survival assay (Figs 1,2).Details of the parameters … data threshold https://gatelodgedesign.com

Special Issue "Autophagy in Tissue Injury and Homeostasis"

WebNov 1, 2024 · Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys, which involves mitochondrial dysfunction and damage in renal tubular cells. Mitophagy is a form of selective autophagy that removes damaged or dysfunctional mitochondria to maintain cellular homeostasis. WebAug 7, 2024 · Mitophagy, a term first proposed by Lemasters (2005), refers to a process by which mitochondria are selectively degraded by autophagy ( Palikaras et al., 2024 ), which has emerged as an important mechanism of mitochondrial quality and quantity control ( Pickles et al., 2024 ). WebNov 26, 2024 · Cisplatin is one of the commonly used anticancer drugs in clinic chemotherapy, but drug resistance is a major therapeutic obstacle for successful treatment. While ginkgolic C17:1 alone induced autophagy and apoptosis in the human hepatoblastoma cells HepG2, it was found to paradoxically inhibit cisplatin-induced … data threshold ga4

Mitophagy alleviates cisplatin-induced renal tubular epithelial …

Category:Frontiers Farrerol Ameliorated Cisplatin-Induced Chronic Kidney ...

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Cisplatin mitophagy

Mitotic catastrophe is a putative mechanism underlying …

WebMar 28, 2024 · Cisplatin chemotherapy often causes acute kidney injury (AKI) in cancer patients. There is increasing evidence that mitochondrial dysfunction plays an … WebCisplatin is a widely used chemotherapeutic agent. Here we show that cisplatin induces apoptosis in renal collecting duct-derived cells (MDCK-C7 cells, resembling principal …

Cisplatin mitophagy

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WebNov 5, 2024 · While cisplatin induced a severe mitophagy defect, mitolysosomes represented by the mCherry signal were markedly higher in Casp9 HZ renal tubule cells exposed to cisplatin (Fig. 6A). Cisplatin induced marked mitochondrial depolarization in kidney tubule cells, which was ameliorated in Casp9 HZ renal tubule cells ( Fig. 6B ). WebBackground: To study the protective effect of berberine (BBR) on cisplatin-induced acute kidney injury (AKI) and its effect on mitophagy. Methods: (I) Male C57BL/6 mice aged 6-8 weeks were randomly divided into control group (saline), cisplatin group (cisplatin), and cisplatin + BBR (5, 10 mg/kg) groups.

WebA total of 407 drugs are known to interact with cisplatin : 77 major drug interactions (291 brand and generic names) 311 moderate drug interactions (1044 brand and generic … WebScience topic Sirtuin 1. A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in ...

WebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. ... Cisplatin has disturbed mitochondrial function and dynamics, dysregulate redox status and induced mitophagy and ...

WebMar 7, 2024 · Recently, some authors believed that miR34a and mitophagy played a role in age-related and drug-induced hearing loss. Our study aimed to explore the involvement of miR-34a/DRP-1-mediated mitophagy in cisplatin-induced ototoxicity. Methods: In this study, C57BL/6 mice and HEI-OC1 cells were treated with cisplatin.

WebFeb 13, 2024 · Cisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of mitochondrial quality control mechanism that degrades damaged mitochondria and maintains cellular homeostasis. Ferropt … data threshold meaningWebSep 18, 2024 · NCBI Bookshelf bitters brush recyclingWebApr 22, 2024 · Cisplatin (CDDP) is commonly used to treat a multitude of tumors including sarcomas, ovarian and cervical cancers. bitters bulky waste collectionWebThe results revealed that cisplatin‑resistant A549 cells contained high levels of APE1, and exhibited elevated levels of autophagy. The levels of m‑APE1 and t‑APE1 protein were increased in the A549/DDP cells when compared with these levels in the A549 cells. bitters + bull lake tomahawkWebApr 22, 2024 · Specifically, levels of the mitophagy receptor BNIP3 are higher both in resistant cells and in ovarian cancer patient samples resistant to platinum-based treatments. Genetic BNIP3 silencing or pharmacological inhibition of autophagosome formation re-sensitizes these cells to CDDP. bitters buy onlineWebJun 1, 2024 · Modulation of cisplatin-induced apoptosis by stimulation or suppression of mitophagy. (A) Cisplatin stimulates apoptosis in HCT116 and SK-N-BE(2) assessed by … data throttled new pay period cricketWebJan 13, 2024 · Abstract. Cisplatin is an efficacious anticancer agent, but its use is limited by ototoxicity and resultant irreversible sensorineural hearing loss. … bitters brush recycling center hours