mDia1 (also known as Dia1, Drf1 for Diaphanous-related formin-1, Diaph1, KIAA4062, p140mDia, mKIAA4062, or D18Wsu154e) is a member of the protein family called the formins and is a Rho effector. It is the mouse version of the diaphanous homolog 1 of Drosophila. mDia1 localizes to cells' mitotic spindle and midbody, … See more The product of the Diap1 (Diaph1) gene consists of 1255 amino acids resulting in a molecular weight of 139,343 daltons. The mDia1 polypeptide chain can be divided into four protein domains: • See more Autoinhibition is achieved through binding of the C-terminal DAD to the N-terminal DID. This interaction inhibits the ability of FH2 to nucleate actin assembly. Rho-GTP binds to the GDB … See more The formin homology protein mDia1 is a Rho GTPase effector protein, which appears to be universally present in eukaryotic cells and participates in: • See more • DIAPH1 See more Nucleation In contrast to the Arp 2/3 complex, formins nucleate the formation of unbranched actin filaments. FH2 domains lack structural similarity to actin but can bind actin monomers with very weak affinity. The FH2 dimer … See more mDia1 was discovered as p140mDia1 by Watanabe et al. in 1997 as a downstream effector of Rho. A mouse embryo cDNA library was … See more • Media related to MDia1 at Wikimedia Commons • Protein Database See more WebApr 24, 2024 · Previously we have shown that Diaphanous-related formin dDia2 is involved in the formation of filopodia. Another key player for the …
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WebMay 22, 2005 · Diaphanous-related formins (DRFs) are a subfamily marked by an additional FH3 domain that is required for subcellular localization 4, and two regulatory regions that allow regulation by Rho... rbc ryerson university
Building platelet phenotypes: diaphanous-related formin 1 …
Web- Caused by mutation in the diaphanous-related formin 1 gene (DIAPH1, 602121.0001) Close. Deafness, autosomal dominant - PS124900 - 75 Entries ... from all available databases. A previously unidentified human gene homologous to the Drosophila gene 'diaphanous' and a mouse gene was revealed by the genomic sequence of 3 BACs. ... WebApr 9, 2024 · DIAPH2 (diaphanous related formin 2); and rs7616661, downstream . of EDEM1 (ER degradation enhancing alpha-mannosidase like . ... (1) pleiotropy is a recurring theme among skin ageing genes, (2 ... WebDec 4, 2024 · diaphanous related formin 1. Gene ID: 1729, updated on 4-Dec-2024. Gene type: protein coding. Also known as: DIA1; DRF1; DFNA1; LFHL1; SCBMS; hDIA1; … rbcs1 rice