WebMar 16, 2024 · We examined the transcriptional response in the prefrontal cortex (PFC) to SD across postnatal development in male mice. We used RNA sequencing to identify functional gene categories that were specifically impacted by SD. We find that SD has dramatically different effects on PFC genes depending on developmental age. WebMar 7, 2006 · Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response.
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WebSep 1, 2014 · SGK1 transcription is regulated by the glucocorticoid receptor , the mineralocorticoid receptor , the progesterone receptor , the vitamin D receptor (VDR), … SGK1 is considered a canonical factor affecting the expression and signal transduction of multiple genes involved in the genesis and development of many human cancers. Abnormal expression of SGK1 has been found in tissue and may hopefully become a useful indicator of cancer progression. See more Serum and glucocorticoid-induced protein kinase 1 (SGK1) was initially cloned as an immediate early gene transcriptionally activated by serum … See more A growing number of investigations suggest that SGK1 is a potential predictor of tumor type, tumor grade and lymph node metastasis in multiple human cancer types (21). Moreover, … See more Although SGK1 plays multiple roles in cancer initiation, progression, metastasis, and treatment response in humans, its expression is modulated by various factors, including a … See more Tumor development is a multistep process that includes sustained proliferation signaling, evasion of growth suppressors, cell death resistance, enabling of replicative immortality, angiogenesis induction, invasion … See more indigo highway.com
Serum/glucocorticoid-regulated kinase 1 (SGK1) is a …
WebApr 11, 2011 · The SGK1 gene is under strict transcriptional control and SGK1 mRNA expression is rapidly induced in response to a variety of external stimuli ( Webster et al., … WebFor Western blot analysis, the adopted antibodies included ENaC-α antibody (70R-13299, Fitzgerald, USA); serum- and glucocorticoid-inducible kinase 1 (SGK1) antibody (ab59337, Abcam, UK), SGK1-phosphor-S422 antibody (ab55281, Abcam), β-actin antibody AC-15 (ab6276 Abcam), goat anti-rabbit IgG H&L HRP-conjugated antibody (ab6721, Abcam), … WebApr 15, 2015 · Along with PKCα, mTORC2 also activates two other members of the AGC family of kinases-SGK1 and AKT. Some of the main downstream effects of mTORC2 are caused by its inhibition of the transcription repressors … indigo high waisted skinny jeans